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Diethyl hydroxymethylphosphonate acts as a reactant for synthesis of α And β-dialkoxyphosphoryl isothiocyanate used in antiproliferative studies, dendritic polyglycerol anions for L-selectin inhibition, phosphonates for anti-HIV-1 activity, homo and copolymers of phosphonated norbornenes, Mitsunobu reactions. It is involved in studies of FBPase inhibition by phosphonic acid-containing thaizoles.
Mateusz Psurski; Katarzyna Błażewska; Anna Gajda; Tadeusz Gajda; Joanna Wietrzyk; Józef Oleksyszyn. Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates. Bioorganic & Medicinal Chemistry Letters.2011, 21 (15), 4572-4576.
Marie Weinhart; Dominic Gröger; Sven Enders; Jens Dernedde; Rainer Haag. Synthesis of dendritic polyglycerol anions and their efficiency toward L-selectin inhibition. Biomacromolecules.2011, 12 (7), 2502-2511.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant