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593-84-0 - Guanidine thiocyanate, 99% - Guanidine rhodanide - B21250 - Alfa Aesar

B21250 Guanidine thiocyanate, 99%

CAS Number
593-84-0
Synonyms
Guanidine rhodanide

Size Price ($) Quantity Availability
100g 61.49
500g 233.81
2500g 922.36
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Guanidine thiocyanate, 99%

MDL
MFCD00013027
EINECS
209-812-1

Chemical Properties

Formula
CH5N3•HSCN
Formula Weight
118.16
Melting point
118-122°
Density
1.29
Sensitivity
Light Sensitive
Solubility
Soluble in water and ethanol

Applications

Guanidine thiocyanate is a useful tool for RNA isolation and protein solubilization. It is involved in the quantification of mRNA from hepatocytes. It acts as a medium for blood smaple lystae in order to maintain the integrity of nucleic acid. It is a chaotropic agent, mainly involved in the extraction of DNA and RNA. It is utilized to deactivate the influenza virus.

Notes

Light sensitive. Incompatible with acids and strong oxidizing agents.

Literature References

Chomczynski, P.; Sacchi, N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat. Protoc. 2006, 1 (2), 581-585.

van Doorn, H. R.; Bruijnesteijn van Coppenraet, E. S.; Duim, B.; Vandenbroucke-Grauls, C. M.; Weel, J. F.; Dankert, J.; Kuijper, E. J.; de Jong, M. D. Silica-guanidinium thiocyanate-based nucleic acid isolation protocol does not improve sensitivity of two commercial tests for detection of Mycobacterium tuberculosis in respiratory samples. Eur. J. Clin. Microbiol. Infect. Dis. 2006, 25 (10), 673-675.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332-H402-H412

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Harmful to aquatic life. Harmful to aquatic life with long lasting effects.

Precautionary Statements: P261-P273-P280-P264-P304+P340-P301+P312-P312-P363-P322-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific measures (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3563461
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
XL1225000

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