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It is used to produce 1-ethyl-1-methyl-4-oxo-piperidinium; iodide when reacted with iodomethane and also in the preparation of 3,5-bisarylmethylene-1-ethyl-4-piperidones. Piperidones exhibit anticancer, anti-inflammatory, and antimicrobial activity, and also inhibit the NF-κB signaling pathway. 4-piperidone are important intermediates in alkaloid synthesis and in the preparation of medicinal agents. Mannich-Michael, and aza-Diels-Alder reactions involving an imino dienophile and a conjugated diene and enones have been applied to the synthesis of piperidine derivatives.
Manuel A. V. Ribeiro da Silva and Joana I. T. A. Cabral. Thermochemistry of Some Derivatives of 2- and 4-Piperidone.J. Chem. Eng. Data,200651(5), 1556-1561.
Nelson J. Leonard, et al. Electric Moments and Transannular Nitrogen-Carbonyl Interaction in Cyclic Aminoketones.J. Am. Chem. Soc.,195779(20), 5476-5479.
Hazard Statements: H227
Precautionary Statements: P210u-P280a-P370+P378a-P403+P235-P501a
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