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B21280 6-Thioguanine, 98%

CAS Number
154-42-7
Synonyms
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol

Stock No. Size Price ($) Quantity Availability
B21280-03 1g 66.50
B21280-06 5g 276.00
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6-Thioguanine, 98%

MDL
MFCD00233553
EINECS
205-827-2

Chemical Properties

Formula
C5H5N5S
Formula Weight
167.19
Melting point
>360°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in dilute solutions of alkali hydroxides and hot alcohol. Insoluble in water.

Applications

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.

Notes

Incompatible with strong oxidizing agents.

Literature References

LaDuke, K. E.; Ehling, S.; Cullen, J. M.; Bäumer, W.; Habil, M. V. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am. J. Vet. Res. 2015, 76 (7), 649-655.

Li, P.; Gu, H.; Zhang, J. Characterization of the Interaction of 6-Thioguanine with Human Serum Albumin by Surface-Enhanced Raman Scattering and Molecular Modeling. Anal. Lett. 2015, 48 (13), 2063-2074.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H341

Toxic if swallowed. Suspected of causing genetic defects.

Precautionary Statements: P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9337
Beilstein
157765
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UP0740000

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