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154-42-7 - 6-Thioguanine, 98% - 2-Amino-6-mercaptopurine - 2-Amino-6-purinethiol - B21280 - Alfa Aesar

B21280 6-Thioguanine, 98%

CAS Number
154-42-7
Synonyms
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol

Size Price ($) Quantity Availability
1g 63.13
5g 201.60
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6-Thioguanine, 98%

MDL
MFCD00233553
EINECS
205-827-2

Chemical Properties

Formula
C5H5N5S
Formula Weight
167.19
Melting point
>360°
Solubility
Soluble in dilute solutions of alkali hydroxides and hot alcohol. Insoluble in water.

Applications

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.

Notes

Incompatible with strong oxidizing agents.

Literature References

LaDuke, K. E.; Ehling, S.; Cullen, J. M.; Bäumer, W.; Habil, M. V. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am. J. Vet. Res. 2015, 76 (7), 649-655.

Li, P.; Gu, H.; Zhang, J. Characterization of the Interaction of 6-Thioguanine with Human Serum Albumin by Surface-Enhanced Raman Scattering and Molecular Modeling. Anal. Lett. 2015, 48 (13), 2063-2074.

GHS Hazard and Precautionary Statements

Hazard Statements: H301

Toxic if swallowed.

Precautionary Statements: P264-P270-P301+P310-P321-P330-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9337
Beilstein
157765
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UP0740000

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