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5-Fluoroorotic Acid, Monohydrate (5-FOA) has become a valuable tool for research in the field of molecular genetics and has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5í-phosphate decarboxylation.
W. M. Macintyre; and M. Zirakzadeh. The crystal and molecular structure of the monohydrate of the rubidium salt of 5-fluoroorotic acid. Acta Cryst., 1964, 171305-1311.
V. H. Bono Jr.; C. C. Cheng; E. Frei III; and M. G. Kelly. Methyl-5-fluoroorotate: Synthesis and Comparison with 5-Fluoroorotic Acid with Respect to Biological Activity and Cell Entry. Cancer Res., 1964, 24513.
Reagent used in the selection of mutant URA3 gene strains of Saccharomyces Cerevisiae: Genetics, 107, 179 (1984); Methods Enzymol., 154, 164 (1987).
Potential antimalarial agent: Antimicrob. Agents Chemother., 40, 914 (1996).
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.