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220141-70-8 - 5-Fluoroorotic acid monohydrate, 98% - 5-Fluorouracil-6-carboxylic acid monohydrate - B21290 - Alfa Aesar

B21290 5-Fluoroorotic acid monohydrate, 98%

CAS Number
220141-70-8
Synonyms
5-Fluorouracil-6-carboxylic acid monohydrate

Size Price ($) Quantity Availability
50mg 60.15
250mg 88.80
1g 282.22
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5-Fluoroorotic acid monohydrate, 98%

MDL
MFCD00150658
EINECS
211-876-0

Chemical Properties

Formula
C5H3FN2O4•H2O
Formula Weight
192.11 (174.09anhy)
Melting point
ca 255° dec.
Solubility
Soluble in water, dimethyl sulfoxide, 50mg in 1ml (1:1 ammonium hydroxide: water) with gentle heating.

Applications

5-Fluoroorotic Acid, Monohydrate (5-FOA) has become a valuable tool for research in the field of molecular genetics and has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5í-phosphate decarboxylation.

Notes

Store in freezer (-20°C). Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

W. M. Macintyre; and M. Zirakzadeh. The crystal and molecular structure of the monohydrate of the rubidium salt of 5-fluoroorotic acid. Acta Cryst., 1964, 171305-1311.

V. H. Bono Jr.; C. C. Cheng; E. Frei III; and M. G. Kelly. Methyl-5-fluoroorotate: Synthesis and Comparison with 5-Fluoroorotic Acid with Respect to Biological Activity and Cell Entry. Cancer Res., 1964, 24513.

Reagent used in the selection of mutant URA3 gene strains of Saccharomyces Cerevisiae: Genetics, 107, 179 (1984); Methods Enzymol., 154, 164 (1987).

Potential antimalarial agent: Antimicrob. Agents Chemother., 40, 914 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4176
Beilstein
181933
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UV7800000

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