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1076-74-0 - 5-Methoxy-2-methylindole, 99+% - B21348 - Alfa Aesar

B21348 5-Methoxy-2-methylindole, 99+%

CAS Number
1076-74-0
Synonyms

Size Price ($) Quantity Availability
1g 30.40
5g 92.40
25g 373.00
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5-Methoxy-2-methylindole, 99+%

MDL
MFCD00005620
EINECS
214-066-5

Chemical Properties

Formula
C10H11NO
Formula Weight
161.20
Melting point
85-88°
Solubility
Soluble in methanol (very faint turbidity.)

Applications

It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Enrico T Nadres, et al. Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.J Org Chem.,201176(2), 471-483.

Teruhisa Tsuchimoto, et al. Reductive alkylation of indoles with alkynes and hydrosilanes under indium catalysis.Org Lett.201113(5), 912-5.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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