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96-54-8 - 1-Methylpyrrole, 99% - B21451 - Alfa Aesar

B21451 1-Methylpyrrole, 99%

CAS Number
96-54-8
Synonyms

Size Price ($) Quantity Availability
100ml 23.04
500ml 77.04
2500ml 274.56
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1-Methylpyrrole, 99%

MDL
MFCD00005345
EINECS
202-513-7

Chemical Properties

Formula
C5H7N
Formula Weight
81.12
Melting point
-57°
Boiling Point
112-113°
Flash Point
15°(59°F)
Density
0.912
Refractive Index
1.4880
Solubility
Soluble in organic solvents such as alcohol and so on, but insoluble in water.

Applications

1-Methylpyrrole, can be used as organic synthetic materials, widely used in medicine. It is also used as a pharmaceutical intermediate.

Notes

Keep away from acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Keep away from acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Stable under normal temperatures and pressures.

Literature References

TT Dang.; R Ahmad.; TT Dang.; H Reinke.; P Langer. Regioselective Suzuki cross-coupling reactions of 2, 3, 4, 5-tetrabromo-1-methylpyrrole. Tetrahedron Letters. 200849 (10), 1698-1700.

JR Carson.; DN McKinstry.; S Wong. 5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents. J. Med. Chem. 197114 (7), 646-647.

Lithiation occurs at the 2-position. Excess n-BuLi in the presence of TMEDA leads to 2,5-dimetallation: J. Chem. Soc. Perkin I, 887 (1977).

Reaction of benzenoid aromatics with lactones under Friedel-Crafts conditions normally results in alkylation. With 1-methylpyrrole and - or δ-lactones in the presence of AlCl3, acylation at the 2-position predominates: Tetrahedron Lett., 36, 6739 (1995).

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302-H315-H335

Highly flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P241-P303+P361+P353-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
104181
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
UX9640000

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