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10238-21-8 - Glybenzcyclamide, 99% - Glibenclamide - Glyburide - B21459 - Alfa Aesar

B21459 Glybenzcyclamide, 99%

CAS Number
10238-21-8
Synonyms
Glibenclamide
Glyburide

Size Price ($) Quantity Availability
25g 77.25
100g 286.34
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Glybenzcyclamide, 99%

MDL
MFCD00056625
EINECS
233-570-6

Chemical Properties

Formula
C23H28ClN3O5S
Formula Weight
494.01
Melting point
171-174°
Solubility
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Applications

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literature References

DG Dills.; J Schneider. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Hormone and metabolic research= Hormone. 199628 (9), 426-429.

M Jab?rek.; V Yarov-Yarovoy.; P Paucek. State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. Hormone and metabolic research= Hormone. 1998273 (9), 13578-13582.

GHS Hazard and Precautionary Statements

Hazard Statements: H303

May be harmful if swallowed.

Precautionary Statements: P312

Call a POISON CENTER or doctor/physician if you feel unwell.

Other References

Harmonized Tariff Code
2935.00
TSCA
No

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