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Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).
DG Dills.; J Schneider. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Hormone and metabolic research= Hormone. 199628 (9), 426-429.
M Jab?rek.; V Yarov-Yarovoy.; P Paucek. State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. Hormone and metabolic research= Hormone. 1998273 (9), 13578-13582.
Hazard Statements: H303
May be harmful if swallowed.
Precautionary Statements: P312a