I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
It is used in the generation of 1,2-di(lithiomethyl)benzene. It is found to accept electrons from Li metal to give a radical anion which is highly effective in the conversion of alkyl halides to alkyllithiums. 4,4?-Di-tert-butylbiphenyl is used in production of homoallylic amine derivatives. It is also used in the preparation of lithium di-tert-butylbiphenylide, a radical anion, superior to sodium or lithium naphthalenides for metalation reactions. Along with lithium, 4,4?-Di-tert-butylbiphenyl catalyzes; reaction of chloromethyl ethyl ether and different carbonyl compounds to yield corresponding hydroxyethers and reductive opening of N-phenylazetidine.
C E Neipp, et.al. The synthesis of homoallylic amines utilizing a cuprate-based 1,2-metalate rearrangement.J Org Chem.200166(2), 531-7.
Guijarro A and Yus M. 4, 4?-Di-tert-butylbiphenyl-catalysed lithiation of chloromethyl ethyl ether: A barbier-type new and easy alternative to ethyl lithiomethyl ether.Tetrahedron Lett., 199334(21), 3487-90.
Accepts electrons from Li metal to give a radical anion which is highly effective in the conversion of alkyl halides to alkyllithiums: Tetrahedron Lett., 1849 (1976); J. Org. Chem., 45, 1924 (1980). For use in the reductive lithiation of epoxides, see: J. Org. Chem., 55, 1528 (1990); Org. Synth. Coll., 9, 306 (1998).
For use in the generation of 1,2-di(lithiomethyl)benzene, see Phthalan, A10217.