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B21481 4-Chloro-2-(methylthio)pyrimidine, 98%

CAS Number
49844-90-8
Synonyms
4-Chloro-2-(methylmercapto)pyrimidine

Stock No. Size Price ($) Quantity Availability
B21481-09 10g 62.30
B21481-18 50g 252.00
B21481-30 250g 1133.00
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4-Chloro-2-(methylthio)pyrimidine, 98%

MDL
MFCD00006083
EINECS
256-500-6

Chemical Properties

Formula
C5H5ClN2S
Formula Weight
160.63
Melting point
ca -2°
Boiling Point
118-120°/9mm
Flash Point
>110°(230°F)
Density
1.380
Refractive Index
1.6 00
Storage & Sensitivity
Store at -20°C. Moisture Sensitive. May form a Precipitate.
Solubility
Not miscible or difficult to mix in water.

Applications

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Notes

Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.

Literature References

Daves GD, et al. Pyrimidines. XIII. 2-and 6-substituted 4-pyrimidinecarboxylic acids.J. Heterocycl. Chem.19641(3), 130-133.

Peter J Manley, et al. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.Bioorg. Med. Chem. Lett.200313(10), 1673-1677.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
118042
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2933.59
TSCA
No

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