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3-(2-Furyl)acrylic acid is a reactant used in the preparation of heteroaryl-substituted bis-trifluoromethyl carbinols and trifluoroacetophenone derivatives malonyl-CoA decarboxylase (MCD) inhibitors.
Wallace, D. et al. Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2007, 17 (4), 1127-1130.
Frederick E. Brot; Myron L. Bender. Use of the specificity constant of .alpha.-chymotrypsin. J. Am. Chem. Soc., 1969 , 91(25), 7187-7191.