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64-77-7 - Tolbutamide, 98% - 1-n-Butyl-3-(p-tolylsulfonyl)urea - B21698 - Alfa Aesar

B21698 Tolbutamide, 98%

CAS Number
64-77-7
Synonyms
1-n-Butyl-3-(p-tolylsulfonyl)urea

Size Price ($) Quantity Availability
10g 45.90
50g 153.00
250g 543.00
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Tolbutamide, 98%

MDL
MFCD00027169
EINECS
200-594-3

Chemical Properties

Formula
C12H18N2O3S
Formula Weight
270.35
Melting point
128-130°
Solubility
Soluble in chloroform.

Applications

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Sullivan-Klose,et.al. The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. 1996, 6 (4), 2702-2705.

Michael Perley, MD; and David M Kipnis, MD. Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects. Diabetes, 1966, 15(12), 867-874.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Precautionary Statements: P261-P280g-P301+P312a-P363-P321-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9507
Beilstein
1984428
Harmonized Tariff Code
2935.90
TSCA
Yes
RTECS
YS4550000

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