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2-(Phenoxymethyl)oxirane is used in the synthesis of hydrazide-containing inhibitors of HIV-1 integrase.
Zhao, H. et al. Hydrazide-Containing Inhibitors of HIV-1 Integrase.J. Med. Chem.199740(6), 937-941.
E Van den Eeckhout; A De Bruyn; H Pepermans; E L Esmans; I Vryens, J Claereboudt; M Claeys; J E Sinsheimer. Adduct formation identification between phenyl glycidyl ether and 2'-deoxyadenosine and thymidine by chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy.Journal of Chromatography A.1991541(1-2), 317-331.
Hazard Statements: H332-H315-H317-H341-H350-H335
Harmful if inhaled. Causes skin irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. May cause respiratory irritation.
Precautionary Statements: P201-P261-P280-P304+P340-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.