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2-(Phenoxymethyl)oxirane is used in the synthesis of hydrazide-containing inhibitors of HIV-1 integrase.
Zhao, H. et al. Hydrazide-Containing Inhibitors of HIV-1 Integrase.J. Med. Chem.199740(6), 937-941.
E Van den Eeckhout; A De Bruyn; H Pepermans; E L Esmans; I Vryens, J Claereboudt; M Claeys; J E Sinsheimer. Adduct formation identification between phenyl glycidyl ether and 2'-deoxyadenosine and thymidine by chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy.Journal of Chromatography A.1991541(1-2), 317-331.
Hazard Statements: H315-H317-H319-H332-H335-H341-H350
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation. Suspected of causing genetic defects. May cause cancer.
Precautionary Statements: P201-P202-P261-P264b-P271-P272-P280-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P333+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant