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A product for proteomics research. Also used as a reagent in the preparation of nitric oxide-donating analogues of Sulindac (S699215), a non-steroidal anti-inflammatory drug that has the ability to prevent colon cancer.
Andrew Nortcliffe; Alexander G. Ekstrom; James R. Black; James A. Ross; Fouad K. Habib; Nigel P. Botting; David OHagan. Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment.Bioorganic & Medicinal Chemistry.201422(2), 756-761.
Pasricha, P., et al. The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis.Gastroenterology.1995109(3), 994-998.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant