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B21810 Indole-5-carbonitrile, 98+%

CAS Number
15861-24-2
Synonyms
5-Cyanoindole

Stock No. Size Price ($) Quantity Availability
B21810-03 1g 49.10
B21810-06 5g 164.00
B21810-14 25g 695.00
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Indole-5-carbonitrile, 98+%

MDL
MFCD00005669
EINECS
239-986-4

Chemical Properties

Formula
C9H6N2
Formula Weight
142.16
Melting point
104-108°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in chloroform, hexane and methanol. Insoluble in water.

Applications

Reactant used for parallel synthesis of dihydroisoquinolines via silver and L-proline co-catalyzed three-component coupling reaction, preparation of novel PPARα/γ dual agonists for potential treatment of metabolic syndrome and IDDM, chemo selective and regioselective preparation of benzoyl indoles, 4,5-dihydrocyclopenta[c]quinolines by palladium-catalyzed ring-expansion reaction alkynes, using O2 as the oxidant and vinylindoles by hydroarylation of alkynes using indium bromide catalyst.

Notes

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Nataliya A Markina; Raffaella Mancuso; Benjamin Neuenswander; Gerald H Lushington; Richard C Larock. Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines. ACS Combinatorial Science., 2011, 13 (3), 265-271.

Wenliang Wu and Weiping Su. Mild and selective Ru-catalyzed formylation and Fe-catalyzed acylation of free (N-H) indoles using anilines as the carbonyl source. Journal of the American Chemical Society, 2011, 133 (31), 11924-11927.

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312+H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
116738
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
NL5993120

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