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Buffer; zwitterionic nondenaturing detergent for solubilizing membrane proteinsCHAPS is used in the laboratory to dissolve biological macromolecules such as proteins. It acts as a non-denaturing solvent used in purification of membrane proteins. It is also useful in conjunction with nonionic detergents like Triton X-100. Further, it is used as a non-denaturing zwitterionic detergent for membrane biochemistry.
Rodi, P. M.; Gianello, M. D. B.; Corregido, M. C.; Gennaro, A. M. Comparative study of the interaction of CHAPS and Triton X-100 with the erythrocyte membrane. Biochim. Biophys. Acta 2014, 1838 (3), 859-866.
Ghosh, A.; Saha, R.; Saha, B. Effect of CHAPS and CPC micelles on Ir(III) catalyzed Ce(IV) oxidation of aliphatic alcohols at room temperature and pressure. J. Mol. Liq. 2014, 196, 223-237.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.