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3674-09-7 - Methyl 2,3-dichloropropionate, 98% - 2,3-Dichloropropionic acid methyl ester - B21993 - Alfa Aesar

B21993 Methyl 2,3-dichloropropionate, 98%

CAS Number
3674-09-7
Synonyms
2,3-Dichloropropionic acid methyl ester

Size Price ($) Quantity Availability
25g 41.41
100g 74.32
500g 378.01
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Methyl 2,3-dichloropropionate, 98%

MDL
MFCD00000944
EINECS
222-940-2

Chemical Properties

Formula
C4H6Cl2O2
Formula Weight
157.00
Boiling Point
91-92°/50mm
Flash Point
87°(188°F)
Density
1.326
Refractive Index
1.4530
Solubility
Soluble in ether, acetone, ethanol.

Applications

Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.

Notes

Store in cool, dry place in tightly closed containers. Store away from strong oxidizing agents, strong bases.

Literature References

Yoshitaka Ohishi; Teruo Nakanishi. Reaction of Epichlorohydrin with Hydroxybenzo[b]furan. Chemical and Pharmaceutical Bulletin. 1983, 31 (10), 3418-3423.

N. Henry; I. Sánchez; A. Sabatié; V. Bénéteau; G. Guillaumet; M.D. Pujol. Synthesis of substituted 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine as new scaffolds for potential bioactive compounds. Tetrahedron. 2006, 62 (10), 2405-2412.

In the presence of N-(Trimethyl­silyl)­diethyl­amine, A18149, methyl 2-chloroacrylate is formed which can then undergo in situ reaction with an aldehyde to give a methyl formylcyclopropanecarboxylate: Tetrahedron Lett., 40, 1523 (1999):

For use in domino bis-annelation reactions, see: Synth. Commun., 29, 2035 (1999).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1701891
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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