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B21993 Methyl 2,3-dichloropropionate, 98%

CAS Number
3674-09-7
Synonyms
2,3-Dichloropropionic acid methyl ester

Stock No. Size Price ($) Quantity Availability
B21993-14 25g 42.30
B21993-22 100g 97.20
B21993-36 500g 382.00
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Methyl 2,3-dichloropropionate, 98%

MDL
MFCD00000944
EINECS
222-940-2

Chemical Properties

Formula
C4H6Cl2O2
Formula Weight
157.00
Boiling Point
91-92°/50mm
Flash Point
87°(188°F)
Density
1.326
Refractive Index
1.4530
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in ether, acetone, ethanol.

Applications

Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.

Notes

Store in cool, dry place in tightly closed containers. Store away from strong oxidizing agents, strong bases.

Literature References

Yoshitaka Ohishi; Teruo Nakanishi. Reaction of Epichlorohydrin with Hydroxybenzo[b]furan. Chemical and Pharmaceutical Bulletin. 1983, 31 (10), 3418-3423.

N. Henry; I. Sánchez; A. Sabatié; V. Bénéteau; G. Guillaumet; M.D. Pujol. Synthesis of substituted 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine as new scaffolds for potential bioactive compounds. Tetrahedron. 2006, 62 (10), 2405-2412.

In the presence of N-(Trimethyl­silyl)­diethyl­amine, A18149, methyl 2-chloroacrylate is formed which can then undergo in situ reaction with an aldehyde to give a methyl formylcyclopropanecarboxylate: Tetrahedron Lett., 40, 1523 (1999):

For use in domino bis-annelation reactions, see: Synth. Commun., 29, 2035 (1999).

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1701891
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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