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tert-Butyl 2,2,2-trichloroacetimidate is used to produce di-tert-butyl peroxide at temperature of -5°C. It may be used in the synthesis of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine, caged building block. It may be used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.
Deborah M Rothman; M Eugenio Vazquez; Elizabeth M Vogel; Barbara Imperiali. Caged phospho-amino acid building blocks for solid-phase peptide synthesis. Journal of Organic Chemistry. 2003, 68 (17), 5150-5154.
Gary T. Wang; Sheldon Wang; Robert Gentles; Thomas Sowina; Clarence J. Maring; Dale J. Kempf; Warren M. Kati; Vincent Stoll;, Kent D. Stewart; Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (1-3), 125-128.
Reagent for preparation of t-butyl ethers and esters under mild conditions: J. Chem. Soc., Perkin 1, 2247 (1985); Tetrahedron Lett., 29, 2483 (1988). See also Appendix 6.
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.