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B22039 tert-Butyl 2,2,2-trichloroacetimidate, 97%

CAS Number
98946-18-0
Synonyms
2,2,2-Trichloroacetimidic acid tert-butyl ester

Stock No. Size Price ($) Quantity Availability
B22039-03 1g 22.20
B22039-06 5g 56.10
B22039-14 25g 191.00
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tert-Butyl 2,2,2-trichloroacetimidate, 97%

MDL
MFCD00077410
EINECS
000-000-0

Chemical Properties

Formula
C6H10Cl3NO
Formula Weight
218.51
Melting point
20-22°
Boiling Point
64-66°/15mm
Flash Point
55°(131°F)
Density
1.222
Refractive Index
1.4570
Storage & Sensitivity
Keep Cold. Moisture Sensitive.
Solubility
Soluble in organic solvents, cyclo hexane.

Applications

tert-Butyl 2,2,2-trichloroacetimidate is used to produce di-tert-butyl peroxide at temperature of -5°C. It may be used in the synthesis of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine, caged building block. It may be used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.

Notes

Moisture sensitive. Store away from strong oxidizing agents, heat, water/ moisture.

Literature References

Deborah M Rothman; M Eugenio Vazquez; Elizabeth M Vogel; Barbara Imperiali. Caged phospho-amino acid building blocks for solid-phase peptide synthesis. Journal of Organic Chemistry. 2003, 68 (17), 5150-5154.

Gary T. Wang; Sheldon Wang; Robert Gentles; Thomas Sowina; Clarence J. Maring; Dale J. Kempf; Warren M. Kati; Vincent Stoll;, Kent D. Stewart; Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (1-3), 125-128.

Reagent for preparation of t-butyl ethers and esters under mild conditions: J. Chem. Soc., Perkin 1, 2247 (1985); Tetrahedron Lett., 29, 2483 (1988). See also Appendix 6.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1770049
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2925.29
TSCA
No

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