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2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.
Ouyang X, et al. Solid support synthesis of 2-substituted dibenz [b, f] oxazepin-11 (10H)-ones< i> via S< sub> N Ar methodology on AMEBA resin.. Tetrahedron . 1999, 55 (10), 2827-34.
Giulianotti M and Nefzi A.. Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support. . Tetrahedron Lett. 2003, 44 (28), 5307-9.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.