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329-98-6 - alpha-Toluenesulfonyl fluoride, 99% - Phenylmethanesulfonyl fluoride - Phenylmethylsulfonyl fluoride - B22146 - Alfa Aesar

B22146 alpha-Toluenesulfonyl fluoride, 99%

CAS Number
329-98-6
Synonyms
Phenylmethanesulfonyl fluoride
Phenylmethylsulfonyl fluoride

Size Price ($) Quantity Availability
1g 18.90
5g 57.47
25g 179.60
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alpha-Toluenesulfonyl fluoride, 99%

MDL
MFCD00007424
EINECS
206-350-2

Chemical Properties

Formula
C7H7FO2S
Formula Weight
174.19
Melting point
92-94°
Sensitivity
Moisture Sensitive
Solubility
Soluble in ether, benzene, anhydrous ethanol, methanol, 2- propane. Hydrolyses in water.

Applications

α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

Notes

Moisture sensitive. Store away from strong oxidizing agents, amines, bases, water/ moisture. Store at 4°C

Literature References

C Pinsky; A K Dua; F S LaBella. Phenylmethylsulfonyl fluoride (PMSF) given systemically produces naloxone-reversible analgesia and potentiates effects of beta-endorphin given centrally. Life Sciences. 1982, 31 (12-13), 1193-1196.

G T James.Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Analytical Biochemistry. 1978, 86 (2), 574-579.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H314-H318

Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2088311
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2904.10
TSCA
Yes
RTECS
XT8040000

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