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B22146 alpha-Toluenesulfonyl fluoride, 99%

CAS Number
329-98-6
Synonyms
Phenylmethanesulfonyl fluoride
Phenylmethylsulfonyl fluoride

Stock No. Size Price ($) Quantity Availability
B22146-03 1g 21.80
B22146-06 5g 59.70
B22146-14 25g 227.00
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alpha-Toluenesulfonyl fluoride, 99%

MDL
MFCD00007424
EINECS
206-350-2

Chemical Properties

Formula
C7H7FO2S
Formula Weight
174.19
Melting point
92-94°
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Soluble in ether, benzene, anhydrous ethanol, methanol, 2- propane. Hydrolyses in water.

Applications

α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

Notes

Moisture sensitive. Store away from strong oxidizing agents, amines, bases, water/ moisture. Store at 4°C

Literature References

C Pinsky; A K Dua; F S LaBella. Phenylmethylsulfonyl fluoride (PMSF) given systemically produces naloxone-reversible analgesia and potentiates effects of beta-endorphin given centrally. Life Sciences. 1982, 31 (12-13), 1193-1196.

G T James.Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Analytical Biochemistry. 1978, 86 (2), 574-579.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H314

Toxic if swallowed. Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2088311
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.99
TSCA
Yes
RTECS
XT8040000

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