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4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.
V. Q. Yen; N. P. Buu-hoi, N. D. Xuong. Fluorinated Isatins and Some of Their Heterocyclic Derivatives. J. Org. Chem. 1958, 23 (12), 1858-1861.
Makoto Ishikawa; Katsumasa Nonoshita; Yoshio Ogino; Yoshikazu Nagae; Daisuke Tsukahara; Hideka Hosaka; Hiroko Maruki; Sumika Ohyam; Riki Yoshimoto; Kaori Sasaki; Yasufumi Nagata; Jun-ichi Eiki; Teruyuki Nishimura. Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (15), 4450-4454.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant