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4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.
V. Q. Yen; N. P. Buu-hoi, N. D. Xuong. Fluorinated Isatins and Some of Their Heterocyclic Derivatives. J. Org. Chem. 1958, 23 (12), 1858-1861.
Makoto Ishikawa; Katsumasa Nonoshita; Yoshio Ogino; Yoshikazu Nagae; Daisuke Tsukahara; Hideka Hosaka; Hiroko Maruki; Sumika Ohyam; Riki Yoshimoto; Kaori Sasaki; Yasufumi Nagata; Jun-ichi Eiki; Teruyuki Nishimura. Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (15), 4450-4454.
Hazard Statements: H302-H312-H331-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.