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B22374 4-(Trifluoromethyl)benzeneboronic acid, 98%

CAS Number
128796-39-4
Synonyms
4-(Trifluoromethyl)phenylboronic acid

Stock No. Size Price ($) Quantity Availability
B22374-03 1g 62.00
B22374-06 5g 187.00
B22374-14 25g 812.00
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4-(Trifluoromethyl)benzeneboronic acid, 98%

MDL
MFCD00151855
EINECS
000-000-0

Chemical Properties

Formula
C7H6BF3O2
Formula Weight
189.93
Melting point
238-242°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO, not in water

Applications

4-(Trifluoromethyl)benzeneboronic acid is used of this drug is to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Cao KS.; Bian HX.; Zheng WH. Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles. Org Biomol Chem. 2015, 13, (23), 6449-52.

Maki T.; Ishihara K.; Yamamoto H. 4,5,6,7-Tetrachlorobenzo[d][1,3,2]dioxaborol- 2-ol as an effective catalyst for the amide condensation of sterically demanding carboxylic acids. Org Lett.2006, 8, (7), 1431-4.

For phosphine-free palladium-catalyzed Suzuki coupling with aryl halides, see: J. Org. Chem., 59, 5034 (1994).

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312+H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3544189
Harmonized Tariff Code
2931.90
TSCA
No

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