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128796-39-4 - 4-(Trifluoromethyl)benzeneboronic acid, 98% - 4-(Trifluoromethyl)phenylboronic acid - B22374 - Alfa Aesar

B22374 4-(Trifluoromethyl)benzeneboronic acid, 98%

CAS Number
128796-39-4
Synonyms
4-(Trifluoromethyl)phenylboronic acid

Size Price ($) Quantity Availability
1g 60.30
5g 193.00
25g 796.00
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4-(Trifluoromethyl)benzeneboronic acid, 98%

MDL
MFCD00151855
EINECS
000-000-0

Chemical Properties

Formula
C7H6BF3O2
Formula Weight
189.93
Melting point
238-242°
Solubility
Soluble in DMSO, not in water

Applications

4-(Trifluoromethyl)benzeneboronic acid is used of this drug is to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Cao KS.; Bian HX.; Zheng WH. Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles. Org Biomol Chem. 2015, 13, (23), 6449-52.

Maki T.; Ishihara K.; Yamamoto H. 4,5,6,7-Tetrachlorobenzo[d][1,3,2]dioxaborol- 2-ol as an effective catalyst for the amide condensation of sterically demanding carboxylic acids. Org Lett.2006, 8, (7), 1431-4.

For phosphine-free palladium-catalyzed Suzuki coupling with aryl halides, see: J. Org. Chem., 59, 5034 (1994).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3544189
Harmonized Tariff Code
2931.90
TSCA
No

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