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A GABAc antagonistImidazole-4-acetic acid monohydrochloride is used in the preparation of imidazolyl-polyethylenimine modified nanoparticles. It is also used to prepare pyridyl and imidazoyl functionalized carboproteins and potential metal ion chelators. Further, it acts as an imidazole derivative with potential antituberculousis properties. In addition to this, it is used in the generation of acyl guanidine inhibitors of beta-secretas.
Hayallah, A. M. Design and Synthesis of New (SecinH3) Derivatives as Potential Cytohesin Inhibitors. Indian. J. Pharm. Sci. 2014, 76 (5), 387-400.
Matsuo, K.; Kioi, Y.; Yasui, R.; Takaoka, Y.; Miki, T.; Fujishima, S. H.; Hamachi, I. One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method. Chem. Sci. 2013, 4 (6), 2573-2580.
Goyal, R.; Bansal, R.; Tyagi, S.; Shukla, Y.; Kumar, P.; Gupta, K. C. 1,4-Butanediol diglycidyl ether (BDE)-crosslinked PEI-g-imidazole nanoparticles as nucleic acid-carriers in vitro and in vivo. Mol. BioSyst. 2011, 7 (6), 2055-2065.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant