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B22515 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 98+%

CAS Number
6976-37-0
Synonyms
Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane
Bis-TRIS

Stock No. Size Price ($) Quantity Availability
B22515-14 25g 35.10
B22515-22 100g 89.00
B22515-36 500g 362.00
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2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 98+%

MDL
MFCD00002853
EINECS
230-237-7

Chemical Properties

Formula
C8H19NO5
Formula Weight
209.24
Melting point
102-105°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (209.2 g/L), at 20°C and alcohol.

Applications

It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.

Notes

Store in cool, dry place in tightly closed containers. Store away from strong oxidizing agents, air.

Literature References

K H Scheller; T H Abel; P E Polanyi; P K Wenk; B E Fischer; H Sigel. Metal ion/buffer interactions. Stability of binary and ternary complexes containing 2-[bis(2-hydroxyethyl)amino]-2(hydroxymethyl)-1,3-propanediol (Bistris) and adenosine 5'-triphosphate (ATP). European Journal of Biochemistry. 1980, 107 (2), 455-466.

H Kosaka; I Tyuma. Production of superoxide anion by N,N-bis(2-hydroxyethyl)-iminotris(hydroxymethyl)methane buffer during oxidation of oxyhemoglobin by nitrite and effect of inositol hexaphosphate on the oxidation. Biochimica et Biophysica Acta. 1982, 709 (2), 187-193.

Buffer: pH range 5.5 - 8.0.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P234-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P390-P501c

Keep only in original container. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2205275
Harmonized Tariff Code
2922.50
TSCA
Yes

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