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108549-23-1 - Dibenzyl diisopropylphosphoramidite, 95% - B22629 - Alfa Aesar

B22629 Dibenzyl diisopropylphosphoramidite, 95%

CAS Number

Size Price ($) Quantity Availability
5g 75.69
25g 260.10
100g 732.80
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Dibenzyl diisopropylphosphoramidite, 95%


Chemical Properties

Formula Weight
Boiling Point
Flash Point
Moisture Sensitive
Soluble in chloroform.


Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.


Moisture sensitive. Store under inert gas. Store at 0°C. Incompatible with oxidizing agents, water/ moisture.

Literature References

D L Clemm; L Sherman; V Boonyaratanakornkit; W T Schrader; N L Weigel; D P Edwards. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Molecular Endocrinology. 2000, 14 (1), 52-65.

Sang Min Lim; Kenneth D Westover; Scott B Ficarro; Rane A Harrison; Hwan Geun Choi; Michael E Pacold; Martin Carrasco; John Hunter; Nam Doo Kim; Ting Xie; Taebo Sim, Pasi A Jänne; Matthew Meyerson; Jarrod A Marto; John R Engen; Nathanael S Gray. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie. 2014, 53 (1), 199-204.

Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron Lett., 29, 979 (1988).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • J61034

    1H-Tetrazole, 0.45M in acetonitrile
  • L00286

    3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water
  • L12215

    4,5-Dicyanoimidazole, 98+%
  • A10140

    Dimedone, 98%
  • A10273

    1-Naphthoic acid, 98%

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