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108549-23-1 - Dibenzyl diisopropylphosphoramidite, 95% - B22629 - Alfa Aesar

B22629 Dibenzyl diisopropylphosphoramidite, 95%

CAS Number
108549-23-1
Synonyms

Size Price ($) Quantity Availability
5g 84.50
25g 280.00
100g 898.00
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Dibenzyl diisopropylphosphoramidite, 95%

MDL
MFCD00191988

Chemical Properties

Formula
C20H28NO2P
Formula Weight
345.43
Boiling Point
130°/0.55mm
Flash Point
69°(156°F)
Density
1.030
Sensitivity
Moisture Sensitive
Solubility
Soluble in chloroform.

Applications

Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.

Notes

Moisture sensitive. Store under inert gas. Store at 0°C. Incompatible with oxidizing agents, water/ moisture.

Literature References

D L Clemm; L Sherman; V Boonyaratanakornkit; W T Schrader; N L Weigel; D P Edwards. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Molecular Endocrinology. 2000, 14 (1), 52-65.

Sang Min Lim; Kenneth D Westover; Scott B Ficarro; Rane A Harrison; Hwan Geun Choi; Michael E Pacold; Martin Carrasco; John Hunter; Nam Doo Kim; Ting Xie; Taebo Sim, Pasi A Jänne; Matthew Meyerson; Jarrod A Marto; John R Engen; Nathanael S Gray. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie. 2014, 53 (1), 199-204.

Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron Lett., 29, 979 (1988).

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2929.90
TSCA
No

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