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B22753 Diethyl dicarbonate, 97%

CAS Number
1609-47-8
Synonyms
Diethyl oxydiformate
Diethyl pyrocarbonate

Stock No. Size Price ($) Quantity Availability
B22753-06 5g 26.30
B22753-14 25g 74.80
B22753-22 100g 252.00
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Diethyl dicarbonate, 97%

MDL
MFCD00009106
EINECS
216-542-8

Chemical Properties

Formula
C6H10O5
Formula Weight
162.14
Boiling Point
93-94°/18mm
Flash Point
69°(156°F)
Density
1.101
Refractive Index
1.3980
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Store under Nitrogen.
Solubility
Miscible with chloroform, ethanol, esters, ketones and hydrocarbons. Slightly miscible with water.

Applications

Ribonuclease inhibitorDiethyl dicarbonate acts as an inhibitor of ryanodine binding to ryanodine/calcium(II) receptor channel. It is useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Further, it inhibits platelet-activating factor acetyl hydrolase. In addition to this, it is involved in the modification reagent for His and Tyr residues in proteins.

Notes

Store in cool place. Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases and ammonia.

Literature References

In the presence of the hindered base lithium dicyclohexylamide (from Dicyclohexyl­amine, A15671), ɑ -ethoxycarbonylation of ketones occurs to give ß -keto esters: Synthesis, 1014 (1984).

Dogandzhiyski, P.; Ghidini, A.; Danneberg, F.; Stro?mberg, R.; Go?bel, M. W. Studies on Tris(2-aminobenzimidazole)-PNA Based Artificial Nucleases: A Comparison of Two Analytical Techniques. Bioconjugate Chem. 2015, 26 (12), 2514-2519.

Zuldesmi, M.; Waki, A.; Kuroda, K.; Okido, M. Hydrothermal treatment of titanium alloys for the enhancement of osteoconductivity. Mater. Sci. Eng., C 2015, 49, 430-435.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H315-H319-H332-H335

Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,7998
Beilstein
637031
Harmonized Tariff Code
2920.90
TSCA
Yes
RTECS
LQ9350000

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