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B22835 Benzo[b]thiophene-2-boronic acid, 98%

CAS Number
98437-23-1
Synonyms
Thianaphthene-2-boronic acid

Stock No. Size Price ($) Quantity Availability
B22835-03 1g 24.30
B22835-06 5g 71.40
B22835-14 25g 235.00
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Benzo[b]thiophene-2-boronic acid, 98%

MDL
MFCD01075674

Chemical Properties

Formula
C8H7BO2S
Formula Weight
178.02
Melting point
ca 255°
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

Benzo[b]thiophene-2-boronic acid is used in the synthesis of phosphorescent sensor for quantification of copper(II) ion, UV promoted phenanthridine syntheses, Preparation of CYP11B1 inhibitors for treatment of cortisol dependent diseases, PDE4 inhibitors, Suzuki-Miyaura cross-coupling reactions.

Notes

Store in cool, dry conditions in a sealed container. Incompatible with oxidizing agents.

Literature References

Frédéric J.J. Bihel; Hélène Justiniano; Martine Schmitt; Malik Hellal; Mohamed A. Ibrahim; Claire Lugnier; Jean-Jacques Bourguigno. New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (21), 6567-6572.

Partha S. Banerjee; Edison S. Zuniga; Iwao Ojima; Isaac S. Carrico. Targeted and armed oncolytic adenovirus via chemoselective modification. Bioorganic & Medicinal Chemistry Letters. 2011, 21, (17), 4985-4988.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1637924
Harmonized Tariff Code
2934.99
TSCA
No

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