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(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.
Frank J. VillaniJr.; Michael J. Costanzo; Ruth R. Inners; Martin S. Mutter; David E. McClure. Determination of enantiomeric purity of tertiary amines by proton NMR of .alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetic acid complexes. J. Org. Chem. 1986, 51 (19), 3715-3718.
Soonsin S. Oh; William M. Butler; Masato Koreeda. Nonempirical confirmations of the absolute configuration of (+)-.alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetic acid. J. Org. Chem. 1989, 54 (19), 4499-4503.
Widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR: J. Org. Chem., 34, 2453 (1969).
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant