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20445-31-2 - (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99% - (+)-Mosher's acid - (+)-MTPA - B22968 - Alfa Aesar

B22968 (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%

CAS Number
20445-31-2
Synonyms
(+)-Mosher's acid
(+)-MTPA

Size Price ($) Quantity Availability
0.1g 38.60
500mg 72.80
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(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%

MDL
MFCD00004184
EINECS
243-829-5

Chemical Properties

Formula
C10H9F3O3
Formula Weight
234.18
Melting point
43-45°
Boiling Point
105-107°/1mm
Flash Point
>110°(230°F)
Density
1.344
Refractive Index
1.4730
Sensitivity
Hygroscopic
Solubility
Soluble in methanol (50 mg/ 1 ml).

Applications

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.

Notes

Hygroscopic. Store under inert gas. Store away from oxidizing agents, moisture.

Literature References

Frank J. VillaniJr.; Michael J. Costanzo; Ruth R. Inners; Martin S. Mutter; David E. McClure. Determination of enantiomeric purity of tertiary amines by proton NMR of .alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetic acid complexes. J. Org. Chem. 1986, 51 (19), 3715-3718.

Soonsin S. Oh; William M. Butler; Masato Koreeda. Nonempirical confirmations of the absolute configuration of (+)-.alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetic acid. J. Org. Chem. 1989, 54 (19), 4499-4503.

Widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR: J. Org. Chem., 34, 2453 (1969).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6280
Beilstein
2215440
Harmonized Tariff Code
2918.99
TSCA
No

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