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304-20-1 - 1-Hydrazinophthalazine hydrochloride, 98% - Hydralazine hydrochloride - 1(2H)-Phthalazinone hydrazone - B22995 - Alfa Aesar

B22995 1-Hydrazinophthalazine hydrochloride, 98%

CAS Number
304-20-1
Synonyms
Hydralazine hydrochloride
1(2H)-Phthalazinone hydrazone

Size Price ($) Quantity Availability
5g 46.80
25g 154.00
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1-Hydrazinophthalazine hydrochloride, 98%

MDL
MFCD00135998
EINECS
206-151-0

Chemical Properties

Formula
C8H8N4•HCl
Formula Weight
196.64
Melting point
ca 275° dec.
Solubility
Soluble in water. Slightly soluble in diethyl ether and alcohol.

Applications

A monoamine oxidase inhibitor1-Hydrazinophthalazine hydrochloride is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. It acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amine oxidase inhibitor. Further, it serves as an antihypertensive.

Notes

Incompatible with strong oxidizing agents.

Literature References

Kruszynska, A. T. Solid-state studies of phthalazinylhydrazones and triazolophthalazines: the role of the nitro group. CrystEngComm 2015, 17 (40), 7702-7716.

Popov, I. D.; Levchenkov, S. I.; Shcherbakov, I. N.; Aleksandrov, G. G.; Starikova, Z. A.; Lukov, V. V.; Kogan, V. A. Molecular and crystal structure of iron(III) and nickel(II) complexes with 1'-phthalazinylhydrazones of heterocyclic carbonyl compounds. J. Struct. Chem. 2015, 56 (1), 102-107.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H351-H361

Toxic if swallowed. Suspected of causing cancer. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4763
Beilstein
3568329
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
TH9000000

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