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Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function. It is a substrate for creatininase.
Cockcroft D.W.; Gault M.H. Prediction of Creatinine Clearance from Serum Creatinine. Nephron. 1976, 17, 31-41.
Schwartz GJ; Brion LP; Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Europe PMC. 1987, 34 (3), 571-590.
Reacts with aromatic aldehydes in a route to derivatives of N-methylphenylalanine: Org. Synth. Coll., 3, 586 (1955):