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B23117 (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%

CAS Number
17257-71-5
Synonyms
(-)-Mosher's acid
(-)-MTPA

Stock No. Size Price ($) Quantity Availability
B23117-ME 500mg 80.50
B23117-88 2.5g 337.00
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%

MDL
MFCD00064200
EINECS
241-292-1

Chemical Properties

Formula
C10H9F3O3
Formula Weight
234.18
Melting point
43-45°
Boiling Point
105-107°/1mm
Flash Point
>110°(230°F)
Density
1.344
Storage & Sensitivity
Keep Cold. Hygroscopic.
Solubility
Readily soluble in hexane, ether, THF, CH2Cl2, benzene.

Applications

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.

Notes

Hygroscopic. Store under inert gas. Store away from oxidizing agents, moisture.

Literature References

Peter Wasserscheid; Andreas Bösmanna and Carsten Bolm. Synthesis and properties of ionic liquids derived from the ‘chiral pool’. Chem. Commun. 2002, (3), 200-201.

Dale E. Ward; Chung K. Rhee. A simple method for the microscale preparation of mosher's acid chloride. Tetrahedron Letters. 1991, 49 (32), 7165-7166.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6280
Beilstein
3591561
Harmonized Tariff Code
2918.99
TSCA
No

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