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16419-60-6 - 2-Methylbenzeneboronic acid, 98% - 2-Methylphenylboronic acid - o-Tolylboronic acid - B23154 - Alfa Aesar

B23154 2-Methylbenzeneboronic acid, 98%

CAS Number
16419-60-6
Synonyms
2-Methylphenylboronic acid
o-Tolylboronic acid

Size Price ($) Quantity Availability
1g 35.10
5g 78.83
25g 263.60
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2-Methylbenzeneboronic acid, 98%

MDL
MFCD00093526
EINECS
000-000-0

Chemical Properties

Formula
C7H9BO2
Formula Weight
135.96
Melting point
ca 162-164°
Solubility
Slightly soluble in water.

Applications

2-Methylbenzeneboronic acid is a reagent used for Pd-catalyzed arylation using Suzuki-Miyaura cross-coupling in water, Ruthenium catalyzed direct arylation reactions, Ligand-free copper-catalyzed coupling reactions, Rhodium-catalyzed asymmetric 1,4-addition reactions. Reagent used in Preparation of chiral monophosphorus ligands in asymmetric Suzuki-Miyaura coupling reaction, Human farnesyl pyrophosphate synthase inhibitors as antitumor agents for multiple myeloma cells

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agent.

Literature References

Navid Dastbaravardeh; Michael Schnürch; Marko D Mihovilovic. Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates. Organic Letters. 2012, 14 (7), 1930-1933.

Isidro Cobo; M Isabel Matheu; Sergio Castillón; Omar Boutureira; Benjamin G Davis. Phosphine-free Suzuki-Miyaura cross-coupling in aqueous media enables access to 2-C-aryl-glycosides. Organic Letters. 2012, 14 (7), 1728-1731.

Conditions for ligand-free Suzuki cross-coupling of arylboronic acids with aryl iodides, catalyzed by Palladium(II)­ acetate, 10516, to give unsymmetrical biphenyls in high yield, are described: Org. Synth., 75, 61 (1997). See Appendix 5.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2935796
Harmonized Tariff Code
2931.90
TSCA
No
RTECS
ED7777777

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