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Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-κB and folic acid synthesis.
Pawel Grobelny; Arijit Mukherjeea and Gautam R. Desiraju. Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid. CrystEngComm. 2011, 13 (13), 4358-4364.
John Gandolfo; Louis A. Weiss; Michael Farthing, George Powers; Kathleen Eagen; Michael Goldberg; Phillip Berman; Marshall Kaplan. 4-Aminosalicylic acid retention enemas in treatment of distal colitis. Digestive Diseases and Sciences. 1987, 32 (7), 700-704.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.