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65-49-6 - 4-Aminosalicylic acid, 98+% - 4-Amino-2-hydroxybenzoic acid - B23289 - Alfa Aesar

B23289 4-Aminosalicylic acid, 98+%

CAS Number
65-49-6
Synonyms
4-Amino-2-hydroxybenzoic acid

Size Price ($) Quantity Availability
100g 22.23
500g 75.15
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4-Aminosalicylic acid, 98+%

MDL
MFCD00007789
EINECS
200-613-5

Chemical Properties

Formula
C7H7NO3
Formula Weight
153.14
Melting point
ca 135-145° dec.
Solubility
Soluble in water (2 g/L) at 20°C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol. Virtually insoluble in benzene, chloroform, and carbon tetrachloride.

Applications

Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-κB and folic acid synthesis.

Notes

Store in cool, dry place in a well sealed container. Store away from oxidizing agents.

Literature References

Pawel Grobelny; Arijit Mukherjeea and Gautam R. Desiraju. Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid. CrystEngComm. 2011, 13 (13), 4358-4364.

John Gandolfo; Louis A. Weiss; Michael Farthing, George Powers; Kathleen Eagen; Michael Goldberg; Phillip Berman; Marshall Kaplan. 4-Aminosalicylic acid retention enemas in treatment of distal colitis. Digestive Diseases and Sciences. 1987, 32 (7), 700-704.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,477
Beilstein
473071
Harmonized Tariff Code
2922.50
TSCA
Yes
RTECS
VO1225000

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