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B23289 4-Aminosalicylic acid, 98+%

CAS Number
65-49-6
Synonyms
4-Amino-2-hydroxybenzoic acid

Stock No. Size Price ($) Quantity Availability
B23289-22 100g 25.80
B23289-36 500g 83.10
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4-Aminosalicylic acid, 98+%

MDL
MFCD00007789
EINECS
200-613-5

Chemical Properties

Formula
C7H7NO3
Formula Weight
153.14
Melting point
ca 135-145° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (2 g/L) at 20°C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol. Virtually insoluble in benzene, chloroform, and carbon tetrachloride.

Applications

Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-κB and folic acid synthesis.

Notes

Store in cool, dry place in a well sealed container. Store away from oxidizing agents.

Literature References

Pawel Grobelny; Arijit Mukherjeea and Gautam R. Desiraju. Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid. CrystEngComm. 2011, 13 (13), 4358-4364.

John Gandolfo; Louis A. Weiss; Michael Farthing, George Powers; Kathleen Eagen; Michael Goldberg; Phillip Berman; Marshall Kaplan. 4-Aminosalicylic acid retention enemas in treatment of distal colitis. Digestive Diseases and Sciences. 1987, 32 (7), 700-704.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,477
Beilstein
473071
Harmonized Tariff Code
2922.50
TSCA
Yes
RTECS
VO1225000

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