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496-76-4 - 2,4,5-Trihydroxypyrimidine, 98% - Isobarbituric acid - B23320 - Alfa Aesar

B23320 2,4,5-Trihydroxypyrimidine, 98%

CAS Number
496-76-4
Synonyms
Isobarbituric acid

2,4,5-Trihydroxypyrimidine, 98%

MDL
MFCD00082987
EINECS
207-829-9

Chemical Properties

Formula
C4H4N2O3
Formula Weight
128.09
Melting point
>300°
Solubility
Soluble in DMSO (Sparingly), Methanol (Sparingly).

Applications

2,4,5-Trihydroxypyrimidine studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. It acts as an antagonist of uracil in the growth of Lactobacillus casei.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials are oxidizing agents.

Literature References

William R Markesbery; Mark A Lovell. DNA oxidation in Alzheimer's disease. Antioxidants and Redox Signaling.2006, 8, (11-12), 2039-2045.

Maria D Aamann; Martin M Sorensen; Christina Hvitby; Brian R Berquist; Meltem Muftuoglu; Jingyan Tian; Nadja C de Souza-Pinto; Morten Scheibye-Knudsen; David M Wilson; Tinna Stevnsner; Vilhelm A Bohr. Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB Journal.2010, 24, (7), 2334-2346.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
127205
Harmonized Tariff Code
2933.59
TSCA
No

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