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B23443 2-Chloroquinoline, 99%

CAS Number
612-62-4
Synonyms

Stock No. Size Price ($) Quantity Availability
B23443-06 5g 87.50
B23443-14 25g 252.00
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2-Chloroquinoline, 99%

MDL
MFCD00006741
EINECS
210-317-8

Chemical Properties

Formula
C9H6ClN
Formula Weight
163.61
Melting point
34-37°
Boiling Point
265-267°
Flash Point
>110°(230°F)
Density
1.230
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in ethanol, ether, methanol, and chloroform. Insoluble in water.

Applications

2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials are oxidizing agents. Store at room temperature.

Literature References

Faisal Hayat; Emma Moseley; Attar Salahuddin; Robyn L Van Zyl; Amir Azam. Antiprotozoal activity of chloroquinoline based chalcones. European Journal of Medicinal Chemistry.2011, 46, (5), 1897-1905.

Mohammed Salem Al-Dosari; Mostafa Mohamed Ghorab; Mansour Sulaiman Al-Said; Yassin Mohammed Nissan. Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents. Chemical & Pharmaceutical Bulletin.2013, 61, (1), 50-58.

Reaction with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors: J. Med. Chem., 37, 3503 (1994):

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
112561
Harmonized Tariff Code
2933.49
TSCA
Yes
RTECS
VB2320000

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