2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.
Faisal Hayat; Emma Moseley; Attar Salahuddin; Robyn L Van Zyl; Amir Azam. Antiprotozoal activity of chloroquinoline based chalcones. European Journal of Medicinal Chemistry.2011, 46, (5), 1897-1905.
Mohammed Salem Al-Dosari; Mostafa Mohamed Ghorab; Mansour Sulaiman Al-Said; Yassin Mohammed Nissan. Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents. Chemical & Pharmaceutical Bulletin.2013, 61, (1), 50-58.
Reaction with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors: J. Med. Chem., 37, 3503 (1994):
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280g-P305+P351+P338-P337+P313
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.