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p-Tolyl chlorothionoformate is used in dehydration reactions by cyclic elimination of thiocarbonate esters. It acts as a catalyst in the synthesis of alfa-L-2'-deoxythreofuranosyl nucleoside analogs and alkenes from hindered alcohols.
For examples of the use of aryl chlorothionoformates in dehydration reactions by cyclic elimination of thiocarbonate esters, see Phenyl chlorothionoformate, L00838.
Toti, K. S.; Derudas, M.; McGuigan, C.; Balzarini, J.; Van Calenbergh, S. Synthesis and antiviral evaluation of alpha-l-2'-deoxythreofuranosyl nucleosides. Eur. J. Med. Chem. 2011, 46 (9), 3704-3713.
Varaprasad, C. V.; Ramasamy, K. S.; Hong, Z. Synthesis of some monocyclic-N-acetyl 4'-aza-D-nucleosides. J. Heterocycl. Chem. 2006, 43 (2), 325-336.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P201-P280i-P304+P340-P405-P501a
Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.