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p-Tolyl chlorothionoformate is used in dehydration reactions by cyclic elimination of thiocarbonate esters. It acts as a catalyst in the synthesis of alfa-L-2'-deoxythreofuranosyl nucleoside analogs and alkenes from hindered alcohols.
For examples of the use of aryl chlorothionoformates in dehydration reactions by cyclic elimination of thiocarbonate esters, see Phenyl chlorothionoformate, L00838.
Toti, K. S.; Derudas, M.; McGuigan, C.; Balzarini, J.; Van Calenbergh, S. Synthesis and antiviral evaluation of alpha-l-2'-deoxythreofuranosyl nucleosides. Eur. J. Med. Chem. 2011, 46 (9), 3704-3713.
Varaprasad, C. V.; Ramasamy, K. S.; Hong, Z. Synthesis of some monocyclic-N-acetyl 4'-aza-D-nucleosides. J. Heterocycl. Chem. 2006, 43 (2), 325-336.
Hazard Statements: H314
Causes severe skin burns and eye damage.
Precautionary Statements: P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant