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937-63-3 - p-Tolyl chlorothionoformate, 97% - B23501 - Alfa Aesar

B23501 p-Tolyl chlorothionoformate, 97%

CAS Number
937-63-3
Synonyms

Size Price ($) Quantity Availability
10g 56.80
50g 231.30
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p-Tolyl chlorothionoformate, 97%

MDL
MFCD00014466
EINECS
213-333-3

Chemical Properties

Formula
C8H7ClOS
Formula Weight
186.66
Boiling Point
70-72°/1mm
Flash Point
96°(204°F)
Density
1.210
Refractive Index
1.5740
Sensitivity
Moisture Sensitive
Solubility
Miscible with common organic solvents.

Applications

p-Tolyl chlorothionoformate is used in dehydration reactions by cyclic elimination of thiocarbonate esters. It acts as a catalyst in the synthesis of alfa-L-2'-deoxythreofuranosyl nucleoside analogs and alkenes from hindered alcohols.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

For examples of the use of aryl chlorothionoformates in dehydration reactions by cyclic elimination of thiocarbonate esters, see Phenyl­ chlorothionoformate, L00838.

Toti, K. S.; Derudas, M.; McGuigan, C.; Balzarini, J.; Van Calenbergh, S. Synthesis and antiviral evaluation of alpha-l-2'-deoxythreofuranosyl nucleosides. Eur. J. Med. Chem. 2011, 46 (9), 3704-3713.

Varaprasad, C. V.; Ramasamy, K. S.; Hong, Z. Synthesis of some monocyclic-N-acetyl 4'-aza-D-nucleosides. J. Heterocycl. Chem. 2006, 43 (2), 325-336.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1448986
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2930.90
TSCA
No

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