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1711-05-3 - 3-Methoxybenzoyl chloride, 99% - m-Anisoyl chloride - B23571 - Alfa Aesar

B23571 3-Methoxybenzoyl chloride, 99%

CAS Number
1711-05-3
Synonyms
m-Anisoyl chloride

Size Price ($) Quantity Availability
10g 38.52
50g 106.09
250g 423.84
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3-Methoxybenzoyl chloride, 99%

MDL
MFCD00000673
EINECS
216-975-2

Chemical Properties

Formula
C8H7ClO2
Formula Weight
170.60
Boiling Point
123-125°/15mm
Flash Point
92°(197°F)
Density
1.214
Refractive Index
1.5586
Sensitivity
Moisture Sensitive
Solubility
Soluble in chloroform. Reacts with water.

Applications

3-Methoxybenzoyl chloride is used in the synthesis of 2-arylbenzofuran-based molecules that act against Alzheimer’s disease, combatting symptoms. In addition, it aids in the optimization of dihydropyrrolopyrimidine inhibitors against PI3K (phosphoinositide 3-kinase) resulting in tumor growth inhibition.

Notes

Moisture Sensitive. Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.

Literature References

Stefano Rizzoa; Andrea Tarozzi; Manuela Bartolini; Gregory Da Costa; Alessandra Bisi; Silvia Gobbi; Federica Belluti; Alessia Ligresti; Marco Allarà; Jean-Pierre Monti; Vincenza Andrisano; Vincenzo Di Marzo; Patrizia Hrelia; Angela Rampa. 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents. European Journal of Medicinal Chemistry. 2012, 58, 519-532.

Hatsuo Kawada; Hirosato Ebiike; Masao Tsukazaki; Mitsuaki Nakamura; Kenji Morikami; Kiyoshi Yoshinari; Miyuki Yoshida; Kotaro Ogawa; Nobuo Shimma; Takuo Tsukuda; Jun Ohwada. Bioorganic & Medicinal Chemistry Letters. 2013, 23, 673-678.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
386659
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2918.99
TSCA
No

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