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2-Chlorotoluene is used for permanganate oxidation to give o-chlorobenzoic acid. It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol.
Daniel Dobslaw; Karl-Heinrich Engesser. Degradation of 2-chlorotoluene by Rhodococcus sp. OCT 10. Applied Microbiology and Biotechnology. 2012, 93, 2205-2214.
Katrin Pollmann; Victor Wray and Dietmar H. Pieper. Chloromethylmuconolactones as Critical Metabolites in the Degradation of Chloromethylcatechols: Recalcitrance of 2-Chlorotoluene. Journal of Bacteriology. 2005, 187, (7), 2332-2340.
For permanganate oxidation to give o-chlorobenzoic acid, see: Org. Synth. Coll., 2, 135 (1943).
Hazard Statements: H226-H332-H361d
Flammable liquid and vapour. Harmful if inhaled. Suspected of damaging the unborn child.
Precautionary Statements: P201-P202-P210-P233-P240-P241-P242-P243-P261-P271-P281-P303+P361+P353-P304+P340-P308+P313-P370+P378q-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed or concerned: Get medical advice/attention. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant