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77377-52-7 - N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, 97% - MTBSTFA - TBSTFA - B23760 - Alfa Aesar

B23760 N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, 97%

CAS Number
77377-52-7
Synonyms
MTBSTFA
TBSTFA

Size Price ($) Quantity Availability
1g 30.69
5g 91.38
25g 309.60
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N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, 97%

MDL
MFCD00009671
EINECS
000-000-0

Chemical Properties

Formula
C9H18F3NOSi
Formula Weight
241.33
Boiling Point
168-170°
Flash Point
52°(125°F)
Density
1.023
Refractive Index
1.4020
Sensitivity
Moisture Sensitive
Solubility
Soluble in water (reacts).

Applications

It finds its application in the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from hydrolysis of nitrogen mustards and a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatography-mass spectrometry (GC-MS) analysis and selective O-silylation of N,O-diacylhydroxylamines and GLC derivatization.

Notes

Moisture sensitive. Store away from water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store away from electrostatic charges. Keep ignition sources away.

Literature References

Ali Shareef, et al. Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17α-ethinylestradiol by gas chromatography-mass spectrometry.J. Chromatogr. A.,2006,1108(1), 121-128.

A. Royer, et al. Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide.J. Chromatogr. A.,2006,1108(1), 129-135.

Reactive silylating agent effective in acetonitrile for introduction of the TBDMS group with alcohols, thiols, amines, amides, carboxylic acids, as well as conversion of enolizable carbonyl groups to silyl enol ethers: J. Org. Chem., 47, 3336 (1982). See Appendix 4.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3606546
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2931.90
TSCA
No

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