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Used as a rubefacient, topical vasodilator used to test the efficacy of skin protection compounds (i.e. products designed to provide barriers to chemical warfare agents) and used as a flavoring agent. It is a useful synthetic intermediate. It can be used to prepare biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α in treatment of rheumatoid arthritis.
Qin Y, et al. Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan.Int J Biol Macromol.,2013,6158-62.
Pabst H, et al. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomized controlled trial.Phytother Res.,2013,27(6), 811-7.
Hazard Statements: H319-H317
Causes serious eye irritation. May cause an allergic skin reaction.
Precautionary Statements: P262-P280g-P305+P351+P338
Do not get in eyes, on skin, or on clothing. Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.