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67-20-9 - Nitrofurantoin, 98% - N-(5-Nitro-2-furfurylidene)-1-aminohydantoin - B24079 - Alfa Aesar

B24079 Nitrofurantoin, 98%

CAS Number
67-20-9
Synonyms
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

Size Price ($) Quantity Availability
25g 42.54
100g 98.40
500g 392.80
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Nitrofurantoin, 98%

MDL
MFCD00003224
EINECS
200-646-5

Chemical Properties

Formula
C8H6N4O5
Formula Weight
238.16
Melting point
ca 265° dec.
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in water (<0.01 g/100 ml at 19°C), dimethyl sulfoxide and methanol.

Applications

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.

Literature References

Charles C. McOsker.; Penny M. Fitzpatrick. Nitrofurantoin: Mechanism of action and implications for resistance development in common uropathogens. J. Antimicrob. Chemother. 1994, 33 23-30.

P. R. Hari.; T. Chandy.; C. P. Sharma. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation: Micro and Nano Carriers. 1996, 13 (3), 319-329.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H317-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Harmful if swallowed.

Precautionary Statements: P285-P261-P280-P342+P311-P301+P312-P363-P304+P341-P321-P333+P313-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
MU2800000

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