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B24079 Nitrofurantoin, 98%

CAS Number
67-20-9
Synonyms
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

Stock No. Size Price ($) Quantity Availability
B24079-14 25g 43.80
B24079-22 100g 124.00
B24079-36 500g 506.00
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Nitrofurantoin, 98%

MDL
MFCD00003224
EINECS
200-646-5

Chemical Properties

Formula
C8H6N4O5
Formula Weight
238.16
Melting point
ca 265° dec.
Storage & Sensitivity
Hygroscopic. Light Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Soluble in water (<0.01 g/100 ml at 19°C), dimethyl sulfoxide and methanol.

Applications

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.

Literature References

Charles C. McOsker.; Penny M. Fitzpatrick. Nitrofurantoin: Mechanism of action and implications for resistance development in common uropathogens. J. Antimicrob. Chemother. 1994, 33 23-30.

P. R. Hari.; T. Chandy.; C. P. Sharma. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation: Micro and Nano Carriers. 1996, 13 (3), 319-329.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317-H334-H373

Harmful if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P260-P264b-P270-P272-P280g-P285-P301+P312-P302+P352-P304+P341-P314-P330-P333+P313-P342+P311-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
MU2800000

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