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(-)-2,3-O-Isopropylidene-D-threitol is used in the synthesis of the optically active enantiomorphic 2,3-butanediols. It react with toluene-4-sulfonyl chloride to get O2,O3-isopropylidene-O1,O4-bis-(toluene-4-sulfonyl)-D-threitol.
Brian S. J. Blagg and C. Dale Poulter. Synthesis of 1-Deoxy-d-xylulose and 1-Deoxy-d-xylulose-5-phosphate. J. Org. Chem. 1999, 64 (5), 1508-1511.
Manuel Colera; Ana M. Costero; Pablo Gaviña; Salvador Gil. Synthesis of chiral 18-crown-6 ethers containing lipophilic chains and their enantiomeric recognition of chiral ammonium picrates. Tetrahedron: Asymmetry. 2005, 16 (15), 2673-2679.
Chiral intermediate: J. Am. Chem. Soc., 94, 6429 (1972).