1-Methyl-2-pyridone is used in pharmaceutical industry. A common problem with hydrophobic non-natural base pairsthe inefficient extension following such a base pairis reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem of non-natural bases: mispairs with deoxyadenosine.
J Shailaja, S Karthikeyan.; V Ramamurthy. Cyclodextrin mediated solvent-free enantioselective photocyclization of N-alkyl pyridones.Tetrahedron Lett. 2002, 43 (51),9335-9339 .
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.