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B24250 Naphthalene-1-sulfonyl chloride, 98%

CAS Number
85-46-1
Synonyms

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Bulk/Specialty

Naphthalene-1-sulfonyl chloride, 98%

MDL
MFCD00003984
EINECS
201-609-6

Chemical Properties

Formula
C10H7ClO2S
Formula Weight
226.68
Melting point
66-70°
Boiling Point
194-195°/13mm
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Reacts slowly with water. Soluble in chloroform.

Applications

1-Naphthalenesulfonyl chloride has been used in the preparation of 5?-O-naphthaleneiulfonyldeoxyuridine and 1-sulfonylindazole derivatives. The derivatives of this compound is used for quantitative metabolome analysis New set of isotope reagents, 12C4-, 12C213C2-, and 13C4-5-diethylamino-naphthalene-1-sulfonyl chloride (DensCl), in combination with liquid chromatography Fourier-transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS) is used for improved analysis of the amine- and phenol-containing submetabolome.

Notes

Hygroscopic. Store at dry place. Incompatible with oxidizing agents, bases and acids.

Literature References

Ruokun Zhou.; Kevin Guo.; Liang Li. 5-Diethylamino-naphthalene-1-sulfonyl Chloride (DensCl): A Novel Triplex Isotope Labeling Reagent for Quantitative Metabolome Analysis by Liquid Chromatography Mass Spectrometry. Anal. Chem. 2013, 85 (23),11532-11539 .

Gedalyahu Skorka.; Pessia Shuker.; David Gill.; Jacob Zabicky.;Abraham H. Parola. Fluorescent substrate analog for adenosine deaminase: 3'-O-[5-(dimethylamino)naphthalene-1-sulfonyl]adenosine. Biochemistry. 1981, 20 (11),3103-3109 .

GHS Hazard and Precautionary Statements

Hazard Statements: H314

Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2099333
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2904.99
TSCA
Yes

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