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1-Methylhydantoin is a reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide. 1-Methylhydantoin and 5-hydroxy-1-methylhydantoin were isolated as plant growth regulators from rabbit skin tissue which had been inflamed by inoculation with vaccinia virus.
Kazuharu Ienaga.; Ko Nakamura.; Toshio Goto.; Jin-emon Konishi. Bioactive compounds produced in animal tissues (II); Two hydantoin plant growth regulators isolated from inflamed rabbit skin tissue.Tetrahedron Lett. 1987, 28 (39), 4587-4588 .
Michael C. Archer.; Stephen D. Clark.; Joan E. Thilly.; Steven R. Tannenbaum. Environmental Nitroso Compounds: Reaction of Nitrite with Creatine and Creatinine.Science. 1971, 174 (4016), 1341-1343 .