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127-48-0 - 3,5,5-Trimethyloxazolidine-2,4-dione, 98% - Trimethadione - B24362 - Alfa Aesar

B24362 3,5,5-Trimethyloxazolidine-2,4-dione, 98%

CAS Number
127-48-0
Synonyms
Trimethadione

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3,5,5-Trimethyloxazolidine-2,4-dione, 98%

MDL
MFCD00047084
EINECS
204-845-8

Chemical Properties

Formula
C6H9NO3
Formula Weight
143.14
Melting point
45-48°
Boiling Point
78-80°/5mm
Solubility
Soluble in water 50 g/L.

Applications

3,5,5-Trimethyloxazolidine-2,4-dione is used in the control of absence (petit mal) seizures that are refractory to treatment with other medications. It is used in the treatment of epilepsy.

Notes

Store in a cool, dry place in tightly closed container. Incompatible with oxidizing agents.

Literature References

N Kurata; Y Nishimura; M Iwase; N E Fischer; B K Tang; T Inaba; H Yasuhara. Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998, 28 (11), 1041-1047.

E Tanaka; M Terada; S Misawa. Cytochrome P450 2E1: its clinical and toxicological role. Journal of Clinical Pharmacy and Therapeutics. 2000, 25 (3), 165-175.

GHS Hazard and Precautionary Statements

Hazard Statements: H303-H360

May be harmful if swallowed. May damage fertility or the unborn child.

Precautionary Statements: P201-P280-P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9706
Beilstein
121627
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
RQ2100000

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