1-(Chloromethyl)naphthalene is a key material for synthesis dye pigment and as fluorescent brightening agent. It is employed in synthetic resin and medicine. Palladium-catalyzed nucleophilic dearomatization of chloromethyl naphthalene derivatives produce ortho- or para-substituted carbocycles in satisfactory to excellent yields.
Bo Peng.; Sheng Zhang.; Xiaoqiang Yu.; Xiujuan Feng.; Ming Bao. Nucleophilic Dearomatization of Chloromethyl Naphthalene Derivatives via η3-Benzylpalladium Intermediates: A New Strategy for Catalytic Dearomatization. Org. Lett. 2011, 13 (19), 5402-5405 .
Rajendra P. Singh.; Jean'ne M. Shreeve. Recent Highlights in Electrophilic Fluorination with 1-Chloromethyl-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate). Acc. Chem. Res. 2004, 37 (1),31-44 .
Hazard Statements: H302-H312-H314-H318
Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P280-P305+P351+P338-P309-P310a
Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: