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Methyl dichloroacetate may be used in the diastereoselctive synthesis of bicyclic chlorocyclopropane, as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate, as reagent during CrCl2-induced olefination of aldehydes. It is a reactant involved in nucleophilic substitution reactions with nitro(pentafluorosulfanyl)benzenes, azide-alkyl halide cycloaddition and atom transfer radical addition, Chemical modification of STn antigen for enhancement of synthetic carbohydrate vaccines, three component reaction of arynes with cyclic ethers and active methines, catalytic radical haloalkylation for synthesis of neodysidenin and addition reactions for syntehsis of enantiopure 3,4-diamino esters or amides.
Ana Escribano.; Concepción Pedregal.; Rosario González.; Alejandro Fernández.; Keith Burton.; Gregory A Stephenson. Diastereoselective cyclopropanation of cyclic enones with methyl dichloroacetate anion. Tetrahedron. 2001, 57 (46),9423-9427 .
Yoshiyuki Mido.; Masao Hashimoto. Conformational isomerism of methyl dichloroacetate. An infrared, Raman and 35Cl NQR study. J. Mol. Struct. 1985, 131 (1-2), 71-81 .
Hazard Statements: H227-H332-H315-H319-H335
Combustible liquid. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.