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63503-60-6 - 3-Chlorobenzeneboronic acid, 97% - 3-Chlorophenylboronic acid - B24444 - Alfa Aesar

B24444 3-Chlorobenzeneboronic acid, 97%

CAS Number
63503-60-6
Synonyms
3-Chlorophenylboronic acid

Size Price ($) Quantity Availability
1g 18.45
5g 55.62
25g 190.80
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3-Chlorobenzeneboronic acid, 97%

MDL
MFCD00161354
EINECS
000-000-0

Chemical Properties

Formula
C6H6BClO2
Formula Weight
156.38
Melting point
180-185°
Solubility
Slightly soluble in water. soluble in ether, tetrahydrofuran,, dimethyl sulfoxide, dimethyl formamide, methanol.

Applications

It is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. It is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors6 among others.

Notes

Store at room temperature. Incompatible with oxidizing agents.

Literature References

Robert E. London.; Scott A. Gabel. Fluorine-19 NMR Studies of Fluorobenzeneboronic Acids. 2. Kinetic Characterization of the Interaction with Subtilisin Carlsberg and Model Ligands.J. Am. Chem. Soc. 1994, 116 (6),2570-2575 .

Edward J. Farrington.; Christopher F. J. Barnard.; Elizabeth Rowsell. ;John M. Brown. Ruthenium Complex-Catalysed Heck Reactions of Areneboronic Acids; Mechanism, Synthesis and Halide Tolerance.Advanced Synthesis & Catalysis. 2005, 347 (1),185-195 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2936343
Harmonized Tariff Code
2931.90
TSCA
No

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