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79-30-1 - Isobutyryl chloride, 98% - 2-Methylpropionyl chloride - B24472 - Alfa Aesar

B24472 Isobutyryl chloride, 98%

CAS Number
79-30-1
Synonyms
2-Methylpropionyl chloride

Size Price ($) Quantity Availability
100g 27.60
500g 83.00
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Isobutyryl chloride, 98%

MDL
MFCD00000717
EINECS
201-194-1

Chemical Properties

Formula
(CH3)2CHCOCl
Formula Weight
106.55
Melting point
ca -90°
Boiling Point
91-93°
Flash Point
8°(46°F)
Density
1.017
Refractive Index
1.4070
Sensitivity
Moisture Sensitive
Solubility
Miscible with chloroform, glacial acetic acid, ether, toluene, methylene chloride and benzene.

Applications

Isobutyryl chloride is used in the preparation of fully isobutyramide terminated hyperbranched polyethylenimines. It plays an important role in the separation and identification of shikonin and its ester derivatives in the root epidermis of Echium italicum L. It acts as an acylating agent for the ketimine derivatives of alfa-amino esters, nucleosides and pyrroles. Further, it is used in the preparation of organic peroxides. In addition to this, it is used as an intermediate for dyes, textile auxiliaries and peroxide compounds.

Notes

Moisture sensitive. Incompatible with bases, water, strong oxidizing agents and alcohols.

Literature References

Sparling, B. A.; Tucker, J. K.; Moebius, D. C.; Shair, M. D. Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin. Org. Lett. 2015, 17 (14), 3398-3401.

Lopchuk, J. M.; Gribble, G. W. Total synthesis of atorvastatin via a late-stage, regioselective 1,3-dipolar münchnone cycloaddition. Tetrahedron Lett. 2015, 56 (23), 3208-3211.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H314

Highly flammable liquid and vapour. Causes severe skin burns and eye damage.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
605393
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
UC3944000

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